The first American X-ray

And now a page from our "Sunday Morning"Almanac:January 12th,1896,118 years ago today...the date of an historic rogue X-ray at Davidson College in North Carolina.


On that night,three of Professor Henry L.Smith's students bribed a janitor to let them into the physics lab,where they made an experimental X-ray photograph of items that included two bullets,two rings,and a finger cut from a cadaver.
One of the first portable x-ray machine images in America,it was hardly the last.
The very next month,Professor Smith published his own X-ray photograph of a cadaver's hand.British artist Nick Veasey uses radiographic imaging equipment to create pictures that blend fine art and science.His works show us the inner-workings of everything from a tiny bat (left) to a full-size bus.See more of Veasey's work on his website.19 Photos Incredible x-ray art.
Other,more medically beneficial uses for X-rays soon followed.
Ghostly and mysterious to the layman,X-rays captured everything from fractures to conjoined twins--and captured the popular imagination,too.
From the 1920s to the early '70s,many shoe stores featured x ray machines for sale that supposedly helped to assure a perfect fit--but also emitted poorly-regulated levels of radiation.
Michael Caine used the device to examine mysterious sealed objects in the film,"Billion Dollar Brain"...
...while in the 1978 movie,"Superman,"the visitor from Krypton showed off his X-ray vision to a perhaps too-curious Lois Lane.
Back in the real world,the debut in 2007 of airport security scanners--called backscatter X-ray--that produced all-too-explicit body images raised widespread safety and privacy concerns.
A health study last year by the American Association of Physicists in Medicine concluded:"The risk to the individual is thought to be close to zero"... while the TSA assured the traveling public just last month the scanning software now in use creates "a generic outline of a passenger that is identical for all passengers."< br> ...and also that none of its employees is from Krypton.
The article comes from:http://www.medicalequipment-msl.com/htm/medical-device-news/portable-x-ray-machine.html

The first American X-ray

And now a page from our "Sunday Morning"Almanac:January 12th,1896,118 years ago today...the date of an historic rogue X-ray at Davidson College in North Carolina.


On that night,three of Professor Henry L.Smith's students bribed a janitor to let them into the physics lab,where they made an experimental X-ray photograph of items that included two bullets,two rings,and a finger cut from a cadaver.
One of the first portable x-ray machine images in America,it was hardly the last.
The very next month,Professor Smith published his own X-ray photograph of a cadaver's hand.British artist Nick Veasey uses radiographic imaging equipment to create pictures that blend fine art and science.His works show us the inner-workings of everything from a tiny bat (left) to a full-size bus.See more of Veasey's work on his website.19 Photos Incredible x-ray art.
Other,more medically beneficial uses for X-rays soon followed.
Ghostly and mysterious to the layman,X-rays captured everything from fractures to conjoined twins--and captured the popular imagination,too.
From the 1920s to the early '70s,many shoe stores featured x ray machines for sale that supposedly helped to assure a perfect fit--but also emitted poorly-regulated levels of radiation.
Michael Caine used the device to examine mysterious sealed objects in the film,"Billion Dollar Brain"...
...while in the 1978 movie,"Superman,"the visitor from Krypton showed off his X-ray vision to a perhaps too-curious Lois Lane.
Back in the real world,the debut in 2007 of airport security scanners--called backscatter X-ray--that produced all-too-explicit body images raised widespread safety and privacy concerns.
A health study last year by the American Association of Physicists in Medicine concluded:"The risk to the individual is thought to be close to zero"... while the TSA assured the traveling public just last month the scanning software now in use creates "a generic outline of a passenger that is identical for all passengers."< br> ...and also that none of its employees is from Krypton.
The article comes from:http://www.medicalequipment-msl.com/htm/medical-device-news/portable-x-ray-machine.html

Medical care dream in China

2012-2013 the average annual income of 67,516 yuan of Chinese doctors which cardiothoracic surgeon Health and highest income for 73,851 yuan,73,680 yuan followed neurology and geriatrics 73,657 yuan.Different regions,Beijing Doctors highest income for 104,664 yuan,came in second and third respectively in Shanghai 95,596 yuan and wide Eastern Province,80,963 yuan.Doctors annual income from all sources,the highest proportion of basic salary of 47.7 %,followed by 27.4% for hospitals bonus And 17.7% in bonus sections,these three accounted for 92.8% of total revenue doctors ; while doctors believe that "the hospital or department Room benefits "( 81.2 percent ),"the title and seniority "( 60.4 percent ),"the degree of economic development area "( 53.0% ) Personal income is the most important of the three factors.


From the description of these figures,we can understand that it reflects the fact that:
First,it is China to promote the success of a rural cooperative medical proof.With China's medical reform in depth,the whole China implemented a basic health insurance.While in the process of health care reform,there are still problems in all aspects,but people see a doctor Difficult problem to some extent alleviated.People suffering from serious illness,serious illness,in helping rural cooperative medical care system,the With the opportunity to heal.At present,the grass-roots hospitals,people with Medicare card,can be reimbursed hospitalized 90% of the cost,compared to the previous few thousand people in hospital to hand over a few million,and now only need a few hundred dollars,thousands of Million,reducing the ill economic pressures.Therefore,in patients suffering from serious illness,the Metropolitan to the hospital for inpatient treatment,The number of hospital patients than do rural cooperative medical care is not a lot of time,which increases the workload of doctors,but also to increase The doctor's income.
Second,China's has lots of cheap medical instrument，But China's medical problems still need to continue to deepen reform.In the survey report,the National cardiothoracic surgeon Students with the highest annual income of 73,851 yuan revenue list.This figure shows that surgery is too high a difficult medical patients One big problem,patients need to do cardiothoracic surgery,because fees are too high,and because most in need of high -level Hospitals,and the proportion of low reimbursement,many families to bear the medical expenses of surgery and there is a certain pressure,which is a China's medical reform is a difficult problem.
Third,work pressure,human health,environmental issues have become a killer.In the report,the doctor of revenue in The first three areas of highest:Beijing ( 104,664 yuan ),Shanghai ( 95,596 yuan ) and Guangdong ( 80,963 yuan ).North Beijing,Shanghai and Guangdong,which is a large part of the country working class working pressure,working pressure against the body's Health.Meanwhile,population density,and environmental pollution,but also harm the human body,an increase of patients.Currently China to promote the success of rural cooperative medical care,so that sick people can be hospitalized,which greatly increases The hospitalized patients to the hospital,the hospital's revenue increased substantially.However,people suffering from serious illness to a high level of need When the hospital for treatment,their medical costs are too high,in which surgery and related equipment costs account for a large proportion of which is not Conducive to the healthy development of China's medical industry,the need for reform in these areas.At present,China's doctor-patient relationship Contradiction is more prominent,and health care reform can resolve this contradiction.Thus,doctors and people will benefit.Health for all,this is a beautiful Chinese dream.I hope health care reform in our country in the remuneration of doctors get enough attention,so that doctors get due returns,thereby promoting better medical equipments escort for the people's health.
For more information about http://www.medicalequipment-msl.com/htm/medical-device-news/Medical-care-dream-in-China.html visit our website.

Medical care dream in China

2012-2013 the average annual income of 67,516 yuan of Chinese doctors which cardiothoracic surgeon Health and highest income for 73,851 yuan,73,680 yuan followed neurology and geriatrics 73,657 yuan.Different regions,Beijing Doctors highest income for 104,664 yuan,came in second and third respectively in Shanghai 95,596 yuan and wide Eastern Province,80,963 yuan.Doctors annual income from all sources,the highest proportion of basic salary of 47.7 %,followed by 27.4% for hospitals bonus And 17.7% in bonus sections,these three accounted for 92.8% of total revenue doctors ; while doctors believe that "the hospital or department Room benefits "( 81.2 percent ),"the title and seniority "( 60.4 percent ),"the degree of economic development area "( 53.0% ) Personal income is the most important of the three factors.


From the description of these figures,we can understand that it reflects the fact that:
First,it is China to promote the success of a rural cooperative medical proof.With China's medical reform in depth,the whole China implemented a basic health insurance.While in the process of health care reform,there are still problems in all aspects,but people see a doctor Difficult problem to some extent alleviated.People suffering from serious illness,serious illness,in helping rural cooperative medical care system,the With the opportunity to heal.At present,the grass-roots hospitals,people with Medicare card,can be reimbursed hospitalized 90% of the cost,compared to the previous few thousand people in hospital to hand over a few million,and now only need a few hundred dollars,thousands of Million,reducing the ill economic pressures.Therefore,in patients suffering from serious illness,the Metropolitan to the hospital for inpatient treatment,The number of hospital patients than do rural cooperative medical care is not a lot of time,which increases the workload of doctors,but also to increase The doctor's income.
Second,China's has lots of cheap medical instrument，But China's medical problems still need to continue to deepen reform.In the survey report,the National cardiothoracic surgeon Students with the highest annual income of 73,851 yuan revenue list.This figure shows that surgery is too high a difficult medical patients One big problem,patients need to do cardiothoracic surgery,because fees are too high,and because most in need of high -level Hospitals,and the proportion of low reimbursement,many families to bear the medical expenses of surgery and there is a certain pressure,which is a China's medical reform is a difficult problem.
Third,work pressure,human health,environmental issues have become a killer.In the report,the doctor of revenue in The first three areas of highest:Beijing ( 104,664 yuan ),Shanghai ( 95,596 yuan ) and Guangdong ( 80,963 yuan ).North Beijing,Shanghai and Guangdong,which is a large part of the country working class working pressure,working pressure against the body's Health.Meanwhile,population density,and environmental pollution,but also harm the human body,an increase of patients.Currently China to promote the success of rural cooperative medical care,so that sick people can be hospitalized,which greatly increases The hospitalized patients to the hospital,the hospital's revenue increased substantially.However,people suffering from serious illness to a high level of need When the hospital for treatment,their medical costs are too high,in which surgery and related equipment costs account for a large proportion of which is not Conducive to the healthy development of China's medical industry,the need for reform in these areas.At present,China's doctor-patient relationship Contradiction is more prominent,and health care reform can resolve this contradiction.Thus,doctors and people will benefit.Health for all,this is a beautiful Chinese dream.I hope health care reform in our country in the remuneration of doctors get enough attention,so that doctors get due returns,thereby promoting better medical equipments escort for the people's health.
For more information about http://www.medicalequipment-msl.com/htm/medical-device-news/Medical-care-dream-in-China.html visit our website.

Ultrasound use in the frozen process

Ultrasound (ultrasound machine for sale) used during cryosurgery provides a real-time image of the frozen volume of tissue.Since ultrasound provides a more global view of the frozen tissue than do thermosensors,this imaging technique has come into wide use for monitoring the freeze–thaw cycle,especially for visceral tumors.Ultrasonography offers the possibility of matching the extent of the neoplasm with the volume of tissue frozen in treatment.Frozen tissue is hypoechoic,so the ultrasonic image is black.The edge of the frozen tissue is hyperechoic and appears as a bright line.As freezing continues and the volume of frozen tissue increases,the hyperechoic rim moves away from the probe,leaving the hypoechoic zone behind it.

Therefore the process of tissue freezing can be observed during the cryosurgical procedure.Experience with ultrasound monitoring in hepatic and prostatic cryosurgery is now substantial.The correlation between the ultrasound image and the actual diameter of the frozen tissue is excellent,though it has become evident that ultrasound overestimates the volume of tissue frozen.Much of the frozen volume is obscured by distortions and reflections of the image.Sonography does not provide an image beyond the near edge of the ice because of complete posterior acoustic shadowing (26,27).Some compensation for this limitation can be obtained by viewing the frozen volume from another angle.Three-dimensional (3D) ultrasound machine is in development (28).
The correlation between tissue temperature and the ultrasound image is of considerable importance because effective treatment depends on achieving an appropriate tissue temperature goal.The temperature of frozen tissue cannot be determined from its ultrasonic image.However,the hyperechoic rim of the image is 0 8C and the probe temperature is generally known,so inferences about the steep gradients of temperature in the tissue can be made.For example,using a probe at 160 8C on tissue for 5 min,the 20 8C isotherm is 70% of the distance from the probe to the periphery of the frozen tissue.The 40 8C isotherm,which is commonly used as a goal in tumor therapy,is 60% of the distance from the probe to the frozen boundary.A rapid cooling rate moves the isotherm toward the periphery.
The article comes from:http://www.medicalequipment-msl.com/htm/medical-device-news/portable-ultrasound-machines-for-sale.html

Ultrasound use in the frozen process

Ultrasound (ultrasound machine for sale) used during cryosurgery provides a real-time image of the frozen volume of tissue.Since ultrasound provides a more global view of the frozen tissue than do thermosensors,this imaging technique has come into wide use for monitoring the freeze–thaw cycle,especially for visceral tumors.Ultrasonography offers the possibility of matching the extent of the neoplasm with the volume of tissue frozen in treatment.Frozen tissue is hypoechoic,so the ultrasonic image is black.The edge of the frozen tissue is hyperechoic and appears as a bright line.As freezing continues and the volume of frozen tissue increases,the hyperechoic rim moves away from the probe,leaving the hypoechoic zone behind it.

Therefore the process of tissue freezing can be observed during the cryosurgical procedure.Experience with ultrasound monitoring in hepatic and prostatic cryosurgery is now substantial.The correlation between the ultrasound image and the actual diameter of the frozen tissue is excellent,though it has become evident that ultrasound overestimates the volume of tissue frozen.Much of the frozen volume is obscured by distortions and reflections of the image.Sonography does not provide an image beyond the near edge of the ice because of complete posterior acoustic shadowing (26,27).Some compensation for this limitation can be obtained by viewing the frozen volume from another angle.Three-dimensional (3D) ultrasound machine is in development (28).
The correlation between tissue temperature and the ultrasound image is of considerable importance because effective treatment depends on achieving an appropriate tissue temperature goal.The temperature of frozen tissue cannot be determined from its ultrasonic image.However,the hyperechoic rim of the image is 0 8C and the probe temperature is generally known,so inferences about the steep gradients of temperature in the tissue can be made.For example,using a probe at 160 8C on tissue for 5 min,the 20 8C isotherm is 70% of the distance from the probe to the periphery of the frozen tissue.The 40 8C isotherm,which is commonly used as a goal in tumor therapy,is 60% of the distance from the probe to the frozen boundary.A rapid cooling rate moves the isotherm toward the periphery.
The article comes from:http://www.medicalequipment-msl.com/htm/medical-device-news/portable-ultrasound-machines-for-sale.html

SMM Lead Market Daily Review

SHANGHAI,Jan.7(SMM)–Last Friday,the most active SHFE 1402 lead contract prices(lead sheet for sale) in night trading session started at RMB 14,180/mt and later basically hovered around the price mark. 
 
The metal finally ended the day at RMB 14,155/mt.During the trading session,transactions hit the lowest since the night trading was launched,while positions reached 7,148 lots. 
On Monday,the most active SHFE lead prices opened at RMB 14,150/mt and fluctuated most of the day between RMB 14,150-14,180/mt.Weighed on by declining LME lead prices,SHFE lead prices(sales lead sheet) closed at an intraday low of RMB 14,105/mt,down RMB 150/mt or 1.05%. 
Trading volumes expanded 810 lots to 1,588 lots,while positions gained 418 lots to 7,608 lots.SHFE lead prices still confronted the downside pressures due to negative technical indicators on Monday. 
The article comes from:http://www.medicalequipment-msl.com/htm/medical-device-news/lead-sheet-for-sale.html

SMM Lead Market Daily Review

SHANGHAI,Jan.7(SMM)–Last Friday,the most active SHFE 1402 lead contract prices(lead sheet for sale) in night trading session started at RMB 14,180/mt and later basically hovered around the price mark. 
 
The metal finally ended the day at RMB 14,155/mt.During the trading session,transactions hit the lowest since the night trading was launched,while positions reached 7,148 lots. 
On Monday,the most active SHFE lead prices opened at RMB 14,150/mt and fluctuated most of the day between RMB 14,150-14,180/mt.Weighed on by declining LME lead prices,SHFE lead prices(sales lead sheet) closed at an intraday low of RMB 14,105/mt,down RMB 150/mt or 1.05%. 
Trading volumes expanded 810 lots to 1,588 lots,while positions gained 418 lots to 7,608 lots.SHFE lead prices still confronted the downside pressures due to negative technical indicators on Monday. 
The article comes from:http://www.medicalequipment-msl.com/htm/medical-device-news/lead-sheet-for-sale.html

Doctors discover 3-inch nail lodged inside Chinese man's skull

Yang Yi Kui,a do-it-yourself enthusiast,was feeling sick and discovered,after doctors conducted an portable x-ray machine,that a nail was in his skull near his eye socket.It has been fired there thanks to a cutting machine he was using.The nail has been removed and he is in stable condition. 

A Chinese do-it-yourself enthusiast who felt sick and went to the hospital found out he had a 3-inch nail lodged in his skull. 
Yang Yi Kui is now recovering in hospital after surgeons removed the nail,which was near an eye socket. 
Incredibly,the 55-year-old did not realize the nail was there until it was discovered by x ray machines for sale. 
Yang Yi Kui is expected to be fine and is in stable condition.The nail had gotten into his skill courtesy of a cutting machine while he was working on his home.
"The nail penetrated his eye socket and reached the petrosal bone after passing through the middle cranial fossa,"neurosurgeon Luo Liangsheng said. 
"If we pulled the nail out directly,the surgical risk would be quite high,because the great vessels and nerves might be hurt during the process." 
Yang is in a stable condition in hospital. 
The article comes from:http://www.medicalequipment-msl.com/htm/medical-device-news/x-ray-machines-for-sale.html

Doctors discover 3-inch nail lodged inside Chinese man's skull

Yang Yi Kui,a do-it-yourself enthusiast,was feeling sick and discovered,after doctors conducted an portable x-ray machine,that a nail was in his skull near his eye socket.It has been fired there thanks to a cutting machine he was using.The nail has been removed and he is in stable condition. 

A Chinese do-it-yourself enthusiast who felt sick and went to the hospital found out he had a 3-inch nail lodged in his skull. 
Yang Yi Kui is now recovering in hospital after surgeons removed the nail,which was near an eye socket. 
Incredibly,the 55-year-old did not realize the nail was there until it was discovered by x ray machines for sale. 
Yang Yi Kui is expected to be fine and is in stable condition.The nail had gotten into his skill courtesy of a cutting machine while he was working on his home.
"The nail penetrated his eye socket and reached the petrosal bone after passing through the middle cranial fossa,"neurosurgeon Luo Liangsheng said. 
"If we pulled the nail out directly,the surgical risk would be quite high,because the great vessels and nerves might be hurt during the process." 
Yang is in a stable condition in hospital. 
The article comes from:http://www.medicalequipment-msl.com/htm/medical-device-news/x-ray-machines-for-sale.html

Proton-Beam Radiotherapy

Excluding electron beams,which,as noted,have limitations for treatment of deep tumors,protons are presently the primary beams used in particle-beam therapy.A number of cyclotrons,originally operated as nuclear research facilities,have since been converted for use as medical equipments treatment facilities.A conventional cyclotron i.e.,one that uses a fixed radio frequency (RF) accelerating voltage and a single large conventional magnet is typically limited in proton beam energy to less than 80 MeV,which limits the penetration depth to less than a few cm in tissue.
Hence,these facilities (about one-third of all proton-beam therapy facilities) are generally limited to treatment of shallow tumors,especially eye tumors,or for treatment of certain noncancerous conditions such as age-induced macular degeneration (AMD) (10,12,48,49).As many of these facilities are located in a nuclear research laboratory rather than in or near a hospital,certain treatments requiring fractionated doses or treatment done in combination with other modalities can be problematic.

Treatment of deep-seated tumors requires a proton beam energy of 200 MeV or more.At this energy,the protons’ relativistic increase of mass with increasing velocity requires the use of a large separated-sector cyclotron or high field cyclotron,such as those in use at Indiana University,Massachusetts General Hospital,and elsewhere,or a "race track" synchrotron adapted from high energy physics.An example of the latter is the synchrotron at the Loma Linda proton-beam treatment facility.Synchrotrons are also generally used to produce heavier particles (e.g.,12C ions used for radiation treatmentlead suits for radiation).
All types of proton facilities,owing to the high "magnetic- rigidity" of high energy protons,require a set of large (and costly) beam-switching magnets and patient-treatment gantries.Likewise,raster-scanning the beam and varying the dose-depth required to treat a particular tumor is not trivial,which can be done with electronic elements (active scanning) or with shaped absorbers (passive modulation).
The article comes from:http://www.medicalequipment-msl.com/htm/medical-device-news/Proton-Beam-Radiotherapy%20.html

Proton-Beam Radiotherapy

Excluding electron beams,which,as noted,have limitations for treatment of deep tumors,protons are presently the primary beams used in particle-beam therapy.A number of cyclotrons,originally operated as nuclear research facilities,have since been converted for use as medical equipments treatment facilities.A conventional cyclotron i.e.,one that uses a fixed radio frequency (RF) accelerating voltage and a single large conventional magnet is typically limited in proton beam energy to less than 80 MeV,which limits the penetration depth to less than a few cm in tissue.
Hence,these facilities (about one-third of all proton-beam therapy facilities) are generally limited to treatment of shallow tumors,especially eye tumors,or for treatment of certain noncancerous conditions such as age-induced macular degeneration (AMD) (10,12,48,49).As many of these facilities are located in a nuclear research laboratory rather than in or near a hospital,certain treatments requiring fractionated doses or treatment done in combination with other modalities can be problematic.

Treatment of deep-seated tumors requires a proton beam energy of 200 MeV or more.At this energy,the protons’ relativistic increase of mass with increasing velocity requires the use of a large separated-sector cyclotron or high field cyclotron,such as those in use at Indiana University,Massachusetts General Hospital,and elsewhere,or a "race track" synchrotron adapted from high energy physics.An example of the latter is the synchrotron at the Loma Linda proton-beam treatment facility.Synchrotrons are also generally used to produce heavier particles (e.g.,12C ions used for radiation treatmentlead suits for radiation).
All types of proton facilities,owing to the high "magnetic- rigidity" of high energy protons,require a set of large (and costly) beam-switching magnets and patient-treatment gantries.Likewise,raster-scanning the beam and varying the dose-depth required to treat a particular tumor is not trivial,which can be done with electronic elements (active scanning) or with shaped absorbers (passive modulation).
The article comes from:http://www.medicalequipment-msl.com/htm/medical-device-news/Proton-Beam-Radiotherapy%20.html

Ultrasound nanoparticles may help diabetics avoid the needle

A new nanotechnology-based technique for regulating blood sugar in diabetics may give patients the ability to release insulin painlessly using a small ultrasound device, allowing them to go days between injections – rather than using needles to give themselves multiple insulin injections each day. The technique was developed by researchers at North Carolina State University and the University of North Carolina at Chapel Hill. 
"This is hopefully a big step toward giving diabetics a more painless method of maintaining healthy blood sugar levels," says Dr. Zhen Gu, senior author of a paper on the research and an assistant professor in the joint biomedical engineering program at NC State and UNC-Chapel Hill. 
The technique involves injecting biocompatible and biodegradable nanoparticles into a patient's skin. The nanoparticles are made out of poly(lactic-co-glycolic) acid (PLGA) and are filled with insulin. 
Each of the PLGA nanoparticles is given either a positively charged coating made of chitosan (a biocompatible material normally found in shrimp shells), or a negatively charged coating made of alginate (a biocompatible material normally found in seaweed). When the solution of coated nanoparticles is mixed together, the positively and negatively charged coatings are attracted to each other by electrostatic force to form a "nano-network." Once injected into the subcutaneous layer of the skin, that nano-network holds the nanoparticles together and prevents them from dispersing throughout the body. 
The coated PLGA nanoparticles are also porous. Once in the body, the insulin begins to diffuse from the nanoparticles. But the bulk of the insulin doesn't stray far – it is suspended in a de facto reservoir in the subcutaneous layer of the skin by the electrostatic force of the nano-network. This essentially creates a dose of insulin that is simply waiting to be delivered into the bloodstream. 
When a patient has type 1 or advanced type 2 diabetes, his or her body needs additional insulin, a hormone that transports glucose – or blood sugar – from the bloodstream into the body's cells. These diabetes patients must inject insulin as needed to ensure their blood sugar levels are in the "normal" range. However, these injections can be painful. 
 
A new technique allows diabetics to control insulin release with an injectable nano-network and portable ultrasounddevice. 
Using the new technology developed by Gu's team, a diabetes patient doesn't have to inject a dose of insulin – it's already there. Instead, patients can use a small, hand-held device to apply focused ultrasound waves to the site of the nano-network, painlessly releasing the insulin from its de facto reservoir into the bloodstream. 
The researchers believe the technique works because the ultrasound waves excite microscopic gas bubbles in the tissue, temporarily disrupting nano-network in the subcutaneous layer of the skin. That disruption pushes the nanoparticles apart, relaxing the electrostatic force being exerted on the insulin in the reservoir. This allows the insulin to begin entering the bloodstream – a process hastened by the effect of the ultrasound waves pushing on the insulin. 
"We know this technique works, and we think this is how it works, but we are still trying to determine the precise details," says Dr. Yun Jing, an assistant professor of mechanical engineering at NC State and co-corresponding author of the paper. 
When the ultrasound machine is removed, the electrostatic force reasserts itself and pulls the nanoparticles in the nano-network back together. The nanoparticles then diffuse more insulin, refilling the reservoir. 
"We've done proof-of-concept testing in laboratory mice with type 1 diabetes," Gu says. "We found that this technique achieves a quick release of insulin into the bloodstream, and that the nano-networks contain enough insulin to regulate blood glucose levels for up to 10 days." 
"When the insulin runs out, you have to inject a new nano-network," says Jin Di, lead author of the paper and a Ph.D. student in Gu's research lab. "The previous nano-network is dissolved and fully absorbed into the body in a few weeks." 
"This advance will certainly give millions of people with diabetes worldwide hope that better days are ahead," says Dr. John Buse, director of UNC-Chapel Hill's Diabetes Care Center and deputy director of UNC-Chapel Hill's NIH Clinical and Translational Sciences Award. "We must work to translate these exciting studies in the lab to clinical practice." 
The article comes from:http://www.medicalequipment-msl.com/htm/medical-device-news/cheap-ultrasound-machine-for-sale.html

Ultrasound nanoparticles may help diabetics avoid the needle

A new nanotechnology-based technique for regulating blood sugar in diabetics may give patients the ability to release insulin painlessly using a small ultrasound device, allowing them to go days between injections – rather than using needles to give themselves multiple insulin injections each day. The technique was developed by researchers at North Carolina State University and the University of North Carolina at Chapel Hill. 
"This is hopefully a big step toward giving diabetics a more painless method of maintaining healthy blood sugar levels," says Dr. Zhen Gu, senior author of a paper on the research and an assistant professor in the joint biomedical engineering program at NC State and UNC-Chapel Hill. 
The technique involves injecting biocompatible and biodegradable nanoparticles into a patient's skin. The nanoparticles are made out of poly(lactic-co-glycolic) acid (PLGA) and are filled with insulin. 
Each of the PLGA nanoparticles is given either a positively charged coating made of chitosan (a biocompatible material normally found in shrimp shells), or a negatively charged coating made of alginate (a biocompatible material normally found in seaweed). When the solution of coated nanoparticles is mixed together, the positively and negatively charged coatings are attracted to each other by electrostatic force to form a "nano-network." Once injected into the subcutaneous layer of the skin, that nano-network holds the nanoparticles together and prevents them from dispersing throughout the body. 
The coated PLGA nanoparticles are also porous. Once in the body, the insulin begins to diffuse from the nanoparticles. But the bulk of the insulin doesn't stray far – it is suspended in a de facto reservoir in the subcutaneous layer of the skin by the electrostatic force of the nano-network. This essentially creates a dose of insulin that is simply waiting to be delivered into the bloodstream. 
When a patient has type 1 or advanced type 2 diabetes, his or her body needs additional insulin, a hormone that transports glucose – or blood sugar – from the bloodstream into the body's cells. These diabetes patients must inject insulin as needed to ensure their blood sugar levels are in the "normal" range. However, these injections can be painful. 
 
A new technique allows diabetics to control insulin release with an injectable nano-network and portable ultrasounddevice. 
Using the new technology developed by Gu's team, a diabetes patient doesn't have to inject a dose of insulin – it's already there. Instead, patients can use a small, hand-held device to apply focused ultrasound waves to the site of the nano-network, painlessly releasing the insulin from its de facto reservoir into the bloodstream. 
The researchers believe the technique works because the ultrasound waves excite microscopic gas bubbles in the tissue, temporarily disrupting nano-network in the subcutaneous layer of the skin. That disruption pushes the nanoparticles apart, relaxing the electrostatic force being exerted on the insulin in the reservoir. This allows the insulin to begin entering the bloodstream – a process hastened by the effect of the ultrasound waves pushing on the insulin. 
"We know this technique works, and we think this is how it works, but we are still trying to determine the precise details," says Dr. Yun Jing, an assistant professor of mechanical engineering at NC State and co-corresponding author of the paper. 
When the ultrasound machine is removed, the electrostatic force reasserts itself and pulls the nanoparticles in the nano-network back together. The nanoparticles then diffuse more insulin, refilling the reservoir. 
"We've done proof-of-concept testing in laboratory mice with type 1 diabetes," Gu says. "We found that this technique achieves a quick release of insulin into the bloodstream, and that the nano-networks contain enough insulin to regulate blood glucose levels for up to 10 days." 
"When the insulin runs out, you have to inject a new nano-network," says Jin Di, lead author of the paper and a Ph.D. student in Gu's research lab. "The previous nano-network is dissolved and fully absorbed into the body in a few weeks." 
"This advance will certainly give millions of people with diabetes worldwide hope that better days are ahead," says Dr. John Buse, director of UNC-Chapel Hill's Diabetes Care Center and deputy director of UNC-Chapel Hill's NIH Clinical and Translational Sciences Award. "We must work to translate these exciting studies in the lab to clinical practice." 
The article comes from:http://www.medicalequipment-msl.com/htm/medical-device-news/cheap-ultrasound-machine-for-sale.html